Exon 2周围标记有loxP位点,通过同源重组,将loxP-tk-neo cassette插入上游内含子。在目标细胞中短暂表达Cre重组酶,有助于去除Exon 2和loxP-tk-neo cassette,从而导致含有催化必需的sialylmotif的删除。(来源:J:79167)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count