使用了cos.6I/LnJ-4的cosmid克隆,它带有鼠源Prnp基因。cosmid Prnp序列来自Inbred品系I/LnJ,该品系携带有Prnpb等位基因(第189位的缬氨酸)。通过转基因动物的RT-PCR分析来验证转基因表达。(来源:J:11316)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x SJL)F1
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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