在同源重组的基础上,Exon 3被替换了 neo-mycin 选择座。通过同源保护实验和肝脏和肾脏组织的 Western blot 分析,无论是转录还是蛋白质在纯合突变小鼠中均未检测到。在来自纯合突变小鼠的肝脏和肾微粒体中,证实了功能缺失,因为没有葡萄糖-6-磷酸酶的水解活动。(来源:J:33212)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
插入,基因内删除
--
1
4
18

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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