从1745到2033的核苷酸序列,包括10号和11号外显子的部分以及它们之间的内含子,被替换了 neoquinomycine 选择标记。RT-PCR和测序分析发现了一个异常转录本,它包含了内源基因的前569个密码子,后面跟着75个neo密码子。这项转录本在Northern blot分析中未被检测到,表明它不稳定性。(来源:J:74077)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
37
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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