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中文
通过同源重组，将2-4号外显子替换为GFP-neo cassette。基因靶向事件删除了蛋白质的前440个氨基酸，包括整个信号序列和大部分细胞外的Sema样域。通过E16.5胚胎RNA的RT-PCR分析和1日龄纯合突变仔鼠大脑匀浆的Western分析，证实了基因表达在纯合个体中的缺失。(来源：J:72426)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
