将基因的5' DNase敏感位点1(HS1)替换为一个由诺福克病毒序列(loxP)标记的抗氨苄青霉素基因座,同时HS4-6区域替换为一个由loxP标记的抗羟氨苄青霉素基因座和部分诺福克序列的抗氨苄青霉素基因座,通过同源重组实现这一替换。(来源:J:60714)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count