Exon 1被通过同源重组插入了诺美西林选择标记 cassette,用肾提取物的 Western blot 分析和近端肾小管免疫染色,未在纯合突变小鼠中检测到该蛋白。(来源:J:78606)
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Exon 1 was replaced by a neomycin selection cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice by Western blot analysis of kidney extracts and immunostaining of proximal renal tubules. (J:78606)