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中文
在内源性位点的首编码外显子通过同源重组插入了一个带有IRES-lacZ基因的盒式磁带，后面跟着一个敲除neo基因。通过Northern blot分析肢体软骨和RT-PCR检测关节、胸腺以及全眼组织，对纯合突变小鼠的转录未检测到。对幼年期骨生长板的免疫组化分析证实了蛋白的缺失。(来源：J:78596)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
