这个基因在编码着homeodomain和NK-2特异性区域的exon 2被替换成诺卡因抗性基因座,导致其功能受损。通过在E9.5胚胎上进行原地杂交实验,用1和2号染色体的探针对 homozygous突变体进行了基因表达缺失的确认(来源:J:61335)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
3
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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