通过同源重组,部分exon 4到exon 6被一个无启动子的lacZ-neo cassette替换。使用全长cDNA探针对野生型动物大脑的Northern blot检测未发现基因表达。RT-PCR也未检测到基因转录。对大脑、视网膜和睾丸的蛋白质进行 Western blot分析确认了无基因型。(来源:J:61371)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
插入,基因内删除
--
1
11
17

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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