通过体内表达Cre重组酶,从Vegfatm3Pec中去除了含floxed neo cassette的片段,保留了特异的cDNA替换。产生的等位基因缺失了第六外显子和剪接点,从而产生了一个具有中等溶解性和受体结合特性的单一isoform。通过定量RT-PCR确认了这种isoform的唯一存在。(来源:J:75507)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count