通过体内表达Cre重组酶,从Vegfatm3Pec中去除了含floxed neo cassette的片段,保留了特异的cDNA替换。产生的等位基因缺失了第六外显子和剪接点,从而产生了一个具有中等溶解性和受体结合特性的单一isoform。通过定量RT-PCR确认了这种isoform的唯一存在。(来源:J:75507)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
基因内删除
--
1
1
9

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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