大多数编码基本 helix-loop-helix 区域的exon 2被一个包含IRES-lacZ和neo基因的 cassette 替换。对纯合突变胚胎的RT-PCR分析未检测到转录。β-galactosidase的弱表达,推测由于IRES效率不足,展现出与内源基因相似的表达模式。(来源:J:63415)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
4
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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