这个基因通过同源重组在编码区插入了耐药性诺卡因质粒,导致其功能在实验动物中纯合体的背侧苍白纹(ventral tegmental area, VTA)和纹状体黑质的致密部(dopaminergic cells of substantia nigra pars compacta, SNC)中丧失,经体内原位杂交分析证实(来源:J:31328)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
4
94

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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