通过同源重组,内源基因的整个编码区域被替换了 neoantigen 选择子。对皮肤样本提取的总RNA进行northern blot分析显示,纯合突变小鼠中没有转录本。 Western blot分析和原位杂交均证实了蛋白缺失。(来源:J:65192)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
插入,基因内删除
--
1
--
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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