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中文
通过同源重组，将编码第36到106位氨基酸的激酶域的两个外显子替换为PGK-neo cassette。目标突变位点破坏了对激酶活性必需的酪氨酸44。通过PCR基因型分析，至E14.5时在同卵双胞胎胚胎中检测到了纯合突变。对来自E12.2同卵突变胚胎来源的鼠胚胎成纤维细胞的RT-PCR产物序列分析显示，存在一个从106到318的内含子缺失。然而，使用针对Ikkb C端的抗体进行的 Western blot 检测并未发现蛋白质产物。(来源：J:54323)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
