通过同源重组,将部分exon 3和整个exon 4替换为诺卡因抗性基因座,从而删除了锌结合位点。基因失活通过Northern blot分析了来自纯合突变动物的胚胎成纤维细胞对Il1a和Il1b刺激后的结果进行了确认。(来源:J:46038)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
插入,基因内删除
--
1
1
40

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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