这个基因通过将所有锌指结构的序列替换为一个含荧光素-neomycin-胸腺嘧啶脱氨酶插件(floxed cassette)而失活。随后,通过和一个cre敲除突变品系杂交,去除了这个荧光素-neomycin-胸腺嘧啶脱氨酶插件。通过Southern blot在E15.5日的胚胎中检测到了纯合突变胚胎。RNA保护实验显示,E12.5期纯合突变胚胎的心脏中没有Zfpm2 mRNA(来源:J:62879)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
--
1
7
15

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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