2-4号外显子被通过同源重组替换为了betageo载体。目标突变导致exon1被连接到betageo载体,产生了所有阅读框的终止密码子。在E18.5时,通过western blot分析检测到纯合突变胚胎,它们不表达Nup50蛋白。(来源:J:63241)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count