在exon 1上游约900bp位置插入了loxP位点,而在exon 2下游120bp处则插入了含loxP标记的诺卡因抗性基因座。Cre重组酶通过删除1和2号外显子,这些编码了蛋白质的前33个氨基酸,以及选择性座,剩下一个loxP位点。这个等位基因来源于与Col15a1tm2.1Pih相同的靶向事件。通过Northern blot和转基因小鼠的免疫组化分析,证实了该等位基因无转录和蛋白表达。(来源:J:67212)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
基因内删除
--
1
--
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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