Rarb^tm2.1Ipc

The floxed fragment containing exons 9 and and 10 was excised from Rarbtm2Ipc by the ubiquitous in vivo expression of cre recombinase. The deletion eliminated the majority of the ligand binding domain and introduced a frameshift mutation. Neither isoform produced by the endogenous gene was detected in homozygous mutant mice via immunoblot analysis. (J:75134)