从2号到4号外显子,大约占编码区域的60%,被一个诺卡因选择标记的载体替换。删除区域包含了氨基端激活域和部分羧基端域的序列。对总脾RNA的RT-PCR分析显示,纯合突变小鼠中没有转录本存在。(来源:J:37085)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
插入,基因内删除
--
1
1
9

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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