通过同源重组,部分exon 1和全部exon 2被cre基因和一个含floxed PGK-neo-tk cassette的序列替换。 Western blot结果显示,纯合胚胎不产生Myl2蛋白。敲入的cre基因在E7.5时起源于心室组织,由Myl2启动子驱动表达。(来源:J:45125)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count