通过同源重组,部分exon 1和全部exon 2被cre基因和一个含floxed PGK-neo-tk cassette的序列替换。 Western blot结果显示,纯合胚胎不产生Myl2蛋白。敲入的cre基因在E7.5时起源于心室组织,由Myl2启动子驱动表达。(来源:J:45125)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
插入,基因内删除
--
1
7
136

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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