Tg(Eno2-Casp1-C285G)1Yuan

The transgene is comprised of a dominant negative mutant Casp1 gene carrying a cysteine to glycine substitution at position 285 (C285G) fused to lacZ and the enolase 2 promoter. The enolase 2 promoter was used to direct expression of the transgene to cells of the nervous system. Transgenic animals were identified by PCR genotyping. X-gal staining of transgenic tissues detected transgene expression in the dorsal root ganglion. (J:38779)