人类APP基因,编码APP695.SWE突变(K670N和M671L)的过表达。构建中含有融合了hamster朊蛋白驱动序列的APP基因。通过免疫印迹在转基因小鼠大脑中测量APP表达(文献源:J:29880, J:80638)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x SJL)F1
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1
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717

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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