这个等位基因缺失了2号和3号外显子,它们编码DNA结合的高移动性组域和全部转录激活域。它可以通过Cre重组酶剔除Sox9tm1Gsr中包含2号和3号外显子的loxP标记区域,或者通过同时去除2号和3号外显子以及Sox9tm2Gsr中含loxP标记的neo cassette(Sox9tm1Gsr中已删除)来产生(来源:J:75124)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
10
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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