Tg(TLK2mHEL)2Ccg

A genomic fragment containing the coding exons of the chicken lysozyme gene (also known as hen egg lysozyme, HEL) was linked to a 3.3kb fragment of the rat thyroglobulin promoter and to the mouse H2-Kb transmembrane sequence (which included the extracellular spacer sequence, transmembrane segment, and cytoplasmic tail). Thyroids from mice carrying the transgene showed expression of chicken lysozyme by Western blot; spleen, islets, and thymus did not. (J:78309)