这个构建是在内源性位置通过同源重组整合的,其中5和6号外显子被一个在第4内含子的LoxP位点以及6号内含子的floxed neo cassette flank。floxed的外显子编码了53到113位氨基酸,这包括了大部分的Trp53结合区域(来源:J:75118)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1+
Targeted
插入
--
1
5
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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