这个构建中,编码区的起始部分被一个上游的floxed neo cassette和下游的loxP位点包裹,通过同源重组实现了整合。对脾细胞进行流式细胞术分析后发现,loxP位点和neo cassette的插入并未影响MHC-II表面表达(来源:J:75115)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
插入
--
1
8
70

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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