Prss8^tm1Hum

In addition to an FRT flanked neo cassette and a downstream 5' flank loxP site inserted into intron 2, a 3' flank loxP site was inserted into intron 5. The floxed region contained exons 3 through 5. Northern blot analysis showed reduced levels of transcript in heterozygous and homozygous mutant mice. (J:75109)