全部exon 2和大部分exon 3被新霉素选择座替换。这个删除区域除了包含3' UTR,还编码了成熟蛋白的绝大部分。通过Northern blot分析皮肤和肺组织RNA(后者来自接受OVA处理并随后挑战的鼠),在纯合突变鼠中未检测到转录本。 (来源:原文)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
2
29

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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