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中文
在Il4和Kif3a基因间区的3700碱基序列被替换成一个由loxP序列标记的诺卡因抗性基因座。删除区域包含DNA酶I敏感性位点V和Va，这些位点包含Il4转录的增强子。通过体外表达Cre重组酶，诺卡因基因座得以从分子中剔除。纯合突变小鼠的T淋巴细胞和肥大细胞中，Il4的mRNA和蛋白表达显著降低。(来源：J:78089)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
