Pafah1b1^tm2.2Awb

The mutation is derived from Pafah1b1tm2Awb by mating to a cre expressing transgenic line to remove the PGK-neo cassette and genomic regions between intron 2 and intron 6 loxP sites. The deletion eliminates exons 3-6 encoding amino acids 11-189. Homozygous mutant embryos were observed between E5.5 and E7.5 via Southern blot analysis. (J:49531)