在第二内含子插入了带有PGK-neo cassette的floxed序列,并通过同源重组在第六内含子引入了第三个loxP位点。这个等位基因是部分失活的,因为靶向载体中磷果糖酸激酶-neo cassette的插入干扰了该位置的转录或剪接(J:82268,J:49531)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入
--
1
4
23

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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