Exon 2被删除并替换为诺卡因选择标记,通过Northern blot和RT-PCR分析在纯合突变小鼠中未检测到转录本。通过来自纯合突变小鼠的自然杀伤细胞、巨噬细胞和中性粒细胞的FACS分析,证实了内源性基因产物的缺失。(来源:J:50023)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
插入,基因内删除
--
1
--
52

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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