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中文
在exon 7上游插入了loxP位点，通过同源重组在exon 8下游插入了含TK-neo的敲除-neo cassette。exons 7和8编码蛋白激酶催化域的至关重要部分I、II和III。通过在正确靶向的ES细胞中短暂表达Cre重组酶，去除了包含exons 7和8以及TK-neo cassette的敲除区域。对转基因动物大脑膜的 Western blot 分析证实了基因表达的缺失。（来源：J:59179）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
