Exon 1被一个诺姆林选择座舱的插入打断,这个座舱紧接在起始密码子之后。北向印迹分析显示,纯合突变小鼠中没有转录本。通过睾丸提取物的Western blot分析,证实了Ube2b蛋白的缺失。进一步研究显示,同源的Ube2a基因位点的蛋白产量并未受到靶向事件的影响。(来源:J:35244)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
--
11

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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