整个小鼠Sod1基因,其中第4外显子的第86位由甘氨酸替换为赖氨酸(G86R)的工程变异被用作转录因子。G86R突变对应于人类肌萎缩侧索硬化症(ALS)患者中某些案例中的SOD1 G85R突变。 Founder M3在大脑中显示了高转录因子表达。(来源:J:22628)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/N
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插入
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1
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3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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