Tg(APPV717I)1130Kha

Overexpression of human APP gene encoding APP695.TRImyc (V717I, V721A, and M722V with a 3'-myc tag). The construct contained the APP gene fused to the hamster prion protein promoter. APP expression was measured in brains of transgenic mice by quantitation of immunoblots. This transgenic line was estimated to contain ~74 copies of the transgene. Other lines generated using this construct varied in copy number and severity of phenoytpe. (J:29880)