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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Icmt
tm1Hzo
Alias:
pccmt
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基础信息
表型特征
文献报道
通过体外表达Cre重组酶,去除了包含2到4号外显子的片段。这个被删除的序列编码了65到224号氨基酸。杂合子小鼠的Northern blot分析显示转录水平大约减少了50%,而同卵双胞胎突变胚胎的RT-PCR检测未发现转录物。(来源:J:77742)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
2183607
129S/SvEv
Targeted
基因内删除
--
1
--
1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
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