exons 2和3的部分被新霉素抗性筛选 cassette 替换。 Western blot 检测到来自纯合突变小鼠胚胎成纤维细胞中编码蛋白的缺失(来源:J:77725)
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Portions of exons 2 and 3 were replaced with a neomycin selection cassette. Western blot analysis showed an absence of encoded protien in embryonic fibroblasts derived from homozygous mutant mice. (J:77725)