Log In|Sign Up
中文
Exons 3和4，编码保守的helix-hairpin-helix区域，通过插入耐药性筛选 cassette 被删除。通过RT-PCR分析确认了全长转录本的缺失。相邻的Tsc2表达未受影响。序列分析显示，如果neo基因的转录通过readthrough产生异常剪接的转录本，从exon 2到exon 5的剪接会引入框架移码突变，从而阻止功能蛋白的产生。(来源：J:77767)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
