Exon 3的编码区域,涉及JNK结合区域,被替换了 neoventa选择标记片段。对大脑组织的 Western blot分析显示,纯合突变小鼠中未检测到编码蛋白。(来源:J:77616)
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Exon 3, encoding the JNK-binding domain, was replaced with a neomycin selection cassette. Western blot analysis of brain tissue showed an absence of encoded protein in homozygous mutant mice. (J:77616)