将2-9号外显子替换为带有FRT接头的neo cassette,通过同源重组实现。靶向载体在所有3个阅读框内引入了终止密码子。在纯合突变动物的睾丸中,通过RT-PCR分析,使用针对5和6号外显子的引物检测到基因转录本缺失。(来源:J:72945)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
插入,基因内删除
--
1
2
9

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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