这个等位基因是由Egr2tm3Pch衍生而来,通过Cre介导的重组删除了exon 2和邻接序列。携带Egr2tm3Pch基因的鼠与Tg(Pgk1-cre)1Lni小鼠杂交,后代中筛选出了可遗传性删除的个体。对纯合胚胎进行免疫组化实验显示,这个等位基因编码不出任何可检测到的蛋白质。(来源:J:75128)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
基因内删除
--
1
5
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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