通过同源重组,将编码区域完整的外显子替换为GFP-PGK-neo cassette。E10.5胚胎的原位杂交分析显示,纯合突变体中该基因无表达。在突变动物中检测到的GFP转录本,其分布模式与内源性mRNA相似,但没有荧光信号。(引用:J:46668)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1+
Targeted
插入,基因内删除
--
1
1
45

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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