这个等位基因是由通过Evx1tm1Gld杂合体和携带protamine驱动Cre的转基因小鼠杂交产生的。Cre的表达剪除了编码第3外显子的homeodomain区域和neo基因,将IRES-tau-myc留在了3'非翻译区。对杂合子胚胎横切面的分析显示,tau-myc的表达类似于内源基因。(来源:J:70192)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S/SvEv-Gpi1c
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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