外周区域编码的外显子被替换为编码人类NTRK1受体跨膜区的序列,后面跟着lacZ和neo基因。这个设计是为了产生一个融合蛋白,去掉了纤维连接蛋白III样区域,外周区域仅保留116个羧基末端残基,而细胞质区域全部被lacZ基因替换。lacZ活性在胚胎期可以检测到,但出生后发育阶段检测不到。(来源:J:41127)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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