部分exon4和exons5-7被替换了抗氨苄青霉素抗性基因,通过同源重组,导致最后一个锌指域及整个TRAF域的缺失。通过E12.5胚胎来源的鼠胚胎成纤维细胞(MEFs)的 Western blot分析,证实了纯合突变体中基因表达缺失。(来源:J:76067)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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