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中文
将编码第12到194个氨基酸的exons 2和3替换为PGK-neo载体，通过同源重组。使用exon 2的5'端和exon 3的3'端引物，对野生型小鼠胚胎成纤维细胞（MEFs）进行RT-PCR分析，检测到exon 1到exon 4剪接产生的少量截短mRNA。产物测序确认了exons 2和3的缺失。对同源突变小鼠MEFs的 Western blot分析也检测到了少量的截短蛋白产物。（来源：J:75272）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
