第四外显子编码的双特异性磷酸酶域(DSPD)被通过同源重组替换为了诺卡因抗性基因。通过Northern blot和针对大脑和肝脏组织的同源突变动物中DSPD外显子及前3个上游外显子的RT-PCR分析,验证了基因表达的缺失(来源:J:76688)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
5
45

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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